Antimalarial drugs impact chemical messenger secretion by blood platelets.

ABSTRACT:

Background

Advances in antimalarial drug development are important for combating malaria. Among the currently identified antimalarial drugs, it is suggested that some interact directly with the malarial parasites while others interact indirectly with the parasites. While this approach leads to parasite elimination, little is known about how these antimalarial drugs impact immune cells that are also critical in malarial response.

Methods

Herein, the effects of two common antimalarial drugs, chloroquine and quinine, on platelets were explored at both the bulk level, using high performance liquid chromatography, and the single cell level, using carbon-fiber microelectrode amperometry, to characterize any changes in chemical messenger secretion.

Results

The data reveal th

SUBMITTER: Xiong-Hang K 

PROVIDER: S-EPMC7182713 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature