Association of Circulating Progesterone With Breast Cancer Risk Among Postmenopausal Women.

ABSTRACT:

Importance

The role of endogenous progesterone in the development of breast cancer remains largely unexplored to date, primarily owing to assay sensitivity limitations and low progesterone concentrations in postmenopausal women. Recently identified progesterone metabolites may provide insights as experimental data suggest that 5α-dihydroprogesterone (5αP) concentrations reflect cancer-promoting properties and 3α-dihydroprogesterone (3αHP) concentrations reflect cancer-inhibiting properties.

Objective

To evaluate the association between circulating progesterone and progesterone metabolite levels and breast cancer risk.

Design, setting, and participants

Using a sensitive liquid chromatography-tandem mass spectrometry assay, prediagnostic serum levels of progesterone and

SUBMITTER: Trabert B 

PROVIDER: S-EPMC7182797 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature