Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.

ABSTRACT:

Importance

Direct oral anticoagulants (DOACs) are purported to have fewer drug-drug interactions than warfarin. However, potential interactions with coprescribed medications are still a safety concern. Verapamil hydrochloride and diltiazem hydrochloride are combined P-glycoprotein (P-gp) and CYP3A4 inhibitors and may be associated with increases in the risk of bleeding with DOACs.

Objective

To evaluate the risk of bleeding with DOACs and verapamil or diltiazem using an active comparator design.

Design, setting, and participants

A comparative effectiveness active comparator cohort study was conducted using US population-based data (2010-2015) analyzed between January 1 and July 15, 2019. Data were obtained on 48 442 patients with nonvalvular atrial fibrillation who had

SUBMITTER: Pham P 

PROVIDER: S-EPMC7182798 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature