Design of Ultra-Thin PEO/PDMAEMA Polymer Coatings for Tunable Protein Adsorption.

ABSTRACT: Protein adsorption on solid surfaces provides either beneficial or adverse outcomes, depending on the application. Therefore, the desire to predict, control, and regulate protein adsorption on different surfaces is a major concern in the field of biomaterials. The most widely used surface modification approach to prevent or limit protein adsorption is based on the use of poly (ethylene oxide) (PEO). On the other hand, the amount of protein adsorbed on poly(2-(dimethylamine)ethyl methacrylate) (PDMAEMA) coatings can be regulated by the pH and ionic strength of the medium. In this work, ultra-thin PEO/PDMAEMA coatings were designed from solutions with different ratios of PEO to PDMAEMA, and different molar masses of PEO, to reversibly adsorb and desorb human serum albumin (HSA), human fibrin

SUBMITTER: Bratek-Skicki A 

PROVIDER: S-EPMC7183053 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature