High dimensional model representation of log-likelihood ratio: binary classification with expression data.

ABSTRACT:

Background

Binary classification rules based on a small-sample of high-dimensional data (for instance, gene expression data) are ubiquitous in modern bioinformatics. Constructing such classifiers is challenging due to (a) the complex nature of underlying biological traits, such as gene interactions, and (b) the need for highly interpretable glass-box models. We use the theory of high dimensional model representation (HDMR) to build interpretable low dimensional approximations of the log-likelihood ratio accounting for the effects of each individual gene as well as gene-gene interactions. We propose two algorithms approximating the second order HDMR expansion, and a hypothesis test based on the HDMR formulation to identify significantly dysregulated pairwise interactions. The theory

SUBMITTER: Foroughi Pour A 

PROVIDER: S-EPMC7183128 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature