Volume kinetic analysis of fluid retention after induction of general anesthesia.

ABSTRACT:

Background

Induction of general anesthesia increases the hemodilution resulting from infusion of crystalloid fluid, which is believed to be due to slower distribution caused by arterial hypotension. When normal distribution returns is not known.

Methods

An intravenous infusion of 25 mL kg^- 1 of Ringer's lactate was infused over 30 min to 25 volunteers just after induction of general anesthesia for open abdominal hysterectomy. A two-volume model was fitted to the repeated measurements of the blood hemoglobin concentration and the urinary excretion using mixed-effects modelling software. Individual-specific covariates were added in sequence.

Results

Distribution of infused fluid was interrupted during the first 20 min of the infusions. During this time 16.6 m

SUBMITTER: Hahn RG 

PROVIDER: S-EPMC7183132 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature