Associations of waking cortisol with DHEA and testosterone across the pubertal transition: Effects of threat-related early life stress.

ABSTRACT: Atypical regulation of the hypothalamic-pituitary-adrenal (HPA) axis is a putative mechanism underlying the association between exposure to early life stress (ELS) and the subsequent development of mental and physical health difficulties. Recent research indicates that puberty is a period of HPA-axis plasticity during which the effects of exposure to ELS on cortisol regulation may change. In particular, increases in the sex hormones that drive pubertal maturation, including dehydroepiandrosterone (DHEA) and testosterone, may be implicated in pubertal recalibration of cortisol regulation. In the current study, we examined the associations among levels of objectively-rated threat-related ELS and salivary waking cortisol, DHEA, and testosterone in a sample of 178 adolescents (55 % female) who

SUBMITTER: King LS 

PROVIDER: S-EPMC7183417 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature