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Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis.

ABSTRACT: An extract of Galtonia regalis from the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC₅₀ value less than 1.25 μg/mL. The two known cholestane glycosides 1 and 2 and the five new cholestane glycosides galtonosides A-E (3-7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR and mass spectra. Among these compounds, galtonoside B (4) displayed the most potent antiplasmodial activity, with an IC₅₀ value of 0.214 μM against the drug-resistant Dd2 strain of Plasmodium falciparum.

SUBMITTER: Du Y

PROVIDER: S-EPMC7183436 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis.

Du Yongle Y Martin Brooke A BA Valenciano Ana Lisa AL Clement Jason A JA Goetz Michael M Cassera Maria B MB Kingston David G I DGI

Journal of natural products 20200331 4

An extract of Galtonia regalis from the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC50 value less than 1.25 μg/mL. The two known cholestane glycosides 1 and 2 and the five new cholestane glycosides galtonosides A-E (3-7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR and mass spectra. Among these compounds, galtonoside ...[more]

PMID: 32227943

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