Eculizumab: A Review in Neuromyelitis Optica Spectrum Disorder.

ABSTRACT: The terminal complement protein (C5) inhibitor eculizumab (Soliris^®) is the first agent to be specifically approved in the EU, USA, Canada and Japan for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults who are aquaporin-4 water channel autoantibody (AQP4-IgG) seropositive and (in the EU only) for those with a relapsing course of disease. In the phase III PREVENT trial, eculizumab significantly reduced the risk of adjudicated relapse relative to placebo in patients with AQP4-IgG-seropositive NMOSD, approximately a quarter of whom did not receive concomitant immunosuppressive therapies. The beneficial effect of eculizumab was seen across all patient subgroups analysed and was accompanied by improvements in neurological and functional disability assessments

SUBMITTER: Frampton JE 

PROVIDER: S-EPMC7183484 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature