Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis.

ABSTRACT:

Background

Bisphosphonate coating of dental implants is a promising tool for surface modification aiming to improve the osseointegration process and clinical outcome. The biological effects of bisphosphonates are thought to be mainly associated with osteoclasts inhibition, whereas their effects on osteoblast function are unclear. A potential of bisphosphonate coated surfaces to stimulate osteoblast differentiation was investigated by several in vitro studies with contradictory results. The purpose of this systematic review and meta-analysis was to evaluate the effect of bisphosphonate coated implant surfaces on alkaline phosphatase activity in osteoblasts.

Methods

In vitro studies that assessed alkaline phosphatase activity in osteoblasts following cell culture on bisphospho

SUBMITTER: Wehner C 

PROVIDER: S-EPMC7183598 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature