Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran.

ABSTRACT:

Background

Cancer is a major cause of death in low- and middle-income countries. A large number of studies have shown that some of the metabolic risk factors (MRFs) tend to cluster in individuals. We examined the synergistic effects of multiple MRFs and cancer risk among Iranian adults.

Methods

Among 8593 (3929 men) participants aged ≥ 30 years, the self-organizing map (SOM) was applied to clustering of four MRFs including high fasting plasma glucose (HFPG), high total cholesterol (HTC), high systolic blood pressure (HSBP), and high body mass index (HBMI). The Cox proportional hazards model was used to investigate the association between clusters with cancer incidence during a median of 14.0 years of follow-up.

Results

During the study period, 265 new cases of cancer

SUBMITTER: Ramezankhani A 

PROVIDER: S-EPMC7183600 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature