A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao.

ABSTRACT:

Background and objective

As the pathological mechanisms of AD are complex, increasing evidence have demonstrated Chinese Medicine with multi-ingredients and multi-targets may be more suitable for the treatment of diseases with complex pathogenesis. Therefore, the study was to preliminarily decipher the bioactive compounds and potential mechanisms of Qiong Yu Gao (QYG) for AD prevention and treatment by an integrated network pharmacology approach.

Methods

Putative ingredients of QYG and significant genes of AD were retrieved from public database after screening. Then QYG ingredients target proteins/genes were obtained by target fishing. Compound-target-disease network was constructed using Cytoscape to decipher the mechanism of QYG for AD. KEGG pathway and GO enrichment analy

SUBMITTER: You JS 

PROVIDER: S-EPMC7183652 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature