A quantitative MRI index for assessing the severity of hippocampal sclerosis in temporal lobe epilepsy.

ABSTRACT:

Background

Hippocampal sclerosis (HS) is associated with post-surgery outcome in patients with temporal lobe epilepsy (TLE), and an automated method that quantifies HS severity is still lacking. Here, we aim to propose an MRI-based HS index (HSI) that integrates hippocampal volume and FLAIR signal to measure the severity of HS.

Methods

Forty-two pre-surgery TLE patients were included retrospectively, with T1-weighted (T1W) and FLAIR images acquired from each subject. Two experienced neurosurgeons (W.D. and C.S.) and one neurologist (Q.L.) rated HS severity with a four-class grading scale (normal, mild, moderate and severe) based on both hippocampal volume loss and increased FLAIR signal. A consensus of HS severity for each subject was made by voting among the three visual ra

SUBMITTER: Dou W 

PROVIDER: S-EPMC7183666 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature