Study design factors influencing patients' willingness to participate in clinical research: a randomised vignette-based study.

ABSTRACT:

Background

High patient participation in clinical research reduces selection bias and ensures the generalizability of study findings. We explored study-related factors that may influence patients' willingness to participate in research.

Methods

We submitted by mail two vignettes that described clinical research studies - a drug trial and a diagnostic study - to patients recently discharged from hospital and assessed their willingness to participate. We used a factorial design to randomly allocate three study attributes per vignette: in the drug trial, presumed superiority of new drug versus equipoise, public versus industry funding, and random versus non-random treatment allocation; in the diagnostic study, common versus rare disease, genetic versus protein analysis, and aut

SUBMITTER: Gayet-Ageron A 

PROVIDER: S-EPMC7183682 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature