Association of Cholinergic Muscarinic M4 Receptor Gene Polymorphism with Schizophrenia.

ABSTRACT:

Background

Previous studies have linked muscarinic M4 receptors (CHRM4) to schizophrenia. Specifically, the rs2067482 polymorphism was found to be highly associated with this disease.

Purpose

To test whether rs2067482 and rs72910092 are potential risk factors for schizophrenia and/or pharmacogenetic markers for antipsychotic-induced tardive dyskinesia.

Patients and methods

We genotyped DNA of 449 patients with schizophrenia and 134 healthy controls for rs2067482 and rs72910092 polymorphisms of the CHRM4 gene with the use of the MassARRAY^® System by Agena Bioscience. Mann-Whitney test was used to compare qualitative traits and χ ² test was used for categorical traits.

Results

The frequency of genotypes and alleles of rs7291009

SUBMITTER: Pozhidaev IV 

PROVIDER: S-EPMC7183770 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature