Hof1 plays a checkpoint-related role in MMS-induced DNA damage response in Candida albicans.

ABSTRACT: Cells depend on robust DNA damage recognition and repair systems to maintain genomic integrity for survival in a mutagenic environment. In the pathogenic yeast Candida albicans, a subset of genes involved in the response to DNA damage-induced genome instability and morphological changes has been found to regulate virulence. To better understand the virulence-linked DNA repair network, we screened for methyl methane sulfonate (MMS) sensitivity within the GRACE conditional expression collection and identified 56 hits. One of these potential DNA damage repair-associated genes, a HOF1 conditional mutant, unexpectedly had a previously characterized function in cytokinesis. Deletion of HOF1 resulted in MMS sensitivity and genome instability, suggesting Hof1 acts in the DNA d

SUBMITTER: Feng J 

PROVIDER: S-EPMC7183792 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature