Oncogenic ALK ^F1174L drives tumorigenesis in cutaneous squamous cell carcinoma.

ABSTRACT: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer characterized by increased mortality. Here, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC. Our data demonstrate that the overexpression of the constitutively active, mutated ALK, ALK ^F1174L , is sufficient to initiate the development of cSCC and is 100% penetrant. Moreover, we show that cSCC development upon ALK ^F1174L overexpression is independent of the cell-of-origin. Molecularly, our data demonstrate that ALK ^F1174L cooperates with oncogenic Kras ^G12D and loss of p53, well

SUBMITTER: Gualandi M 

PROVIDER: S-EPMC7184028 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature