Rose Bengal Photodynamic Antimicrobial Therapy for Patients With Progressive Infectious Keratitis: A Pilot Clinical Study.

ABSTRACT: PURPOSE:To report clinical outcomes of rose bengal photodynamic antimicrobial therapy (RB-PDAT) as an adjunct treatment for severe, progressive infectious keratitis. DESIGN:Consecutive interventional case series. METHODS:Patients with progressive infectious keratitis unresponsive to standard medical therapy underwent RB-PDAT at the Bascom Palmer Eye Institute from January 2016 through March 2018. RB-PDAT was performed by applying a solution of rose bengal (0.1% or 0.2% RB in balanced salt solution) to the de-epithelialized cornea for 30 minutes, followed by irradiation with a 6 mW/cm² custom-made green LED source for 15 minutes (5.4 J/cm²). RESULTS:The current study included 18 patients (7 male and 11 female) ranging from 17 to 83 years old. Acanthamoeba was the most

SUBMITTER: Naranjo A 

PROVIDER: S-EPMC7184264 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature