Risk of gout flares after vaccination: a prospective case cross-over study.

ABSTRACT:

Objectives

The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares.

Methods

We conducted an online case-crossover study of patients with gout to examine the association between vaccination and gout flares. We collected information through the Internet on exposures to potential risk factors, including vaccinations, during 2-day hazard periods prior to gout flare and 2-day control periods without a flare. Conditional logistic regression was used to adjust for covariates.

Results

There were 517 participants with gout (mean age 55 years, 79% male) who experienced gout f

SUBMITTER: Yokose C 

PROVIDER: S-EPMC7184318 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature