Dynamic network properties of the interictal brain determine whether seizures appear focal or generalised.

ABSTRACT: Current explanatory concepts suggest seizures emerge from ongoing dynamics of brain networks. It is unclear how brain network properties determine focal or generalised seizure onset, or how network properties can be described in a clinically-useful manner. Understanding network properties would cast light on seizure-generating mechanisms and allow to quantify to which extent a seizure is focal or generalised. Functional brain networks were estimated in segments of scalp-EEG without interictal discharges (68 people with epilepsy, 38 controls). Simplified brain dynamics were simulated using a computer model. We introduce: Critical Coupling (C_c), the ability of a network to generate seizures; Onset Index (OI), the tendency of a region to generate seizures; and Participation Index (

SUBMITTER: Woldman W 

PROVIDER: S-EPMC7184577 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature