Innate Immune Functions of Astrocytes are Dependent Upon Tumor Necrosis Factor-Alpha.

ABSTRACT: Acute inflammation is a key feature of innate immunity that initiates clearance and repair in infected or damaged tissues. Alternatively, chronic inflammation is implicated in numerous disease processes. The contribution of neuroinflammation to the pathogenesis of neurological conditions, including infection, traumatic brain injury, and neurodegenerative diseases, has become increasingly evident. Potential drivers of such neuroinflammation include toll-like receptors (TLRs). TLRs confer a wide array of functions on different cell types in the central nervous system (CNS). Importantly, how TLR activation affects astrocyte functioning is unclear. In the present study, we examined the role of TLR2/4 signaling on various astrocyte functions (i.e., proliferation, pro-inflammatory mediator produ

SUBMITTER: Rodgers KR 

PROVIDER: S-EPMC7184618 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature