Sleep deprivation directly following eyeblink-conditioning impairs memory consolidation.

ABSTRACT: The relation between sleep and different forms of memory formation continues to be a relevant topic in our daily life. Sleep has been found to affect cerebellum-dependent procedural memory formation, but it remains to be elucidated to what extent the level of sleep deprivation directly after motor training also influences our ability to store and retrieve memories. Here, we studied the effect of disturbed sleep in mice during two different time-windows, one covering the first four hours following eyeblink conditioning (EBC) and another window following the next period of four hours. Compared to control mice with sleep ad libitum, the percentage of conditioned responses and their amplitude were impaired when mice were deprived of sleep directly after conditioning. This impairment was still

SUBMITTER: De Zeeuw CI 

PROVIDER: S-EPMC7184677 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature