Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs.

ABSTRACT: ILCs and T helper cells have been shown to exert bi-directional regulation in mice. However, how crosstalk between ILCs and CD4⁺ T cells influences immune function in humans is unknown. Here we show that human intestinal ILCs co-localize with T cells in healthy and colorectal cancer tissue and display elevated HLA-DR expression in tumor and tumor-adjacent areas. Although mostly lacking co-stimulatory molecules ex vivo, intestinal and peripheral blood (PB) ILCs acquire antigen-presenting characteristics triggered by inflammasome-associated cytokines IL-1β and IL-18. IL-1β drives the expression of HLA-DR and co-stimulatory molecules on PB ILCs in an NF-κB-dependent manner, priming them as efficient inducers of cytomegalovirus-specific memory CD4⁺ T-cell responses. This

SUBMITTER: Rao A 

PROVIDER: S-EPMC7184749 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature