Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation.

ABSTRACT: The importance of genetic ancestry characterization is increasing in genomic implementation efforts, and clinical pharmacogenomic guidelines are being published that include population-specific recommendations. Our aim was to test the ability of focused clinical pharmacogenomic SNP panels to estimate individual genetic ancestry (IGA) and implement population-specific pharmacogenomic clinical decision-support (CDS) tools. Principle components and STRUCTURE were utilized to assess differences in genetic composition and estimate IGA among 1572 individuals from 1000 Genomes, two independent cohorts of Caucasians and African Americans (AAs), plus a real-world validation population of patients undergoing pharmacogenomic genotyping. We found that clinical pharmacogenomic SNP panels accurately est

SUBMITTER: Hernandez W 

PROVIDER: S-EPMC7184888 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature