Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes.

ABSTRACT:

Background

In Southeast Asia, people are often coinfected with different species of malaria (Plasmodium falciparum [Pf] and Plasmodium vivax [Pv]) as well as with multiple clones of the same species. Whether particular species or clones within mixed infections are more readily transmitted to mosquitoes remains unknown.

Methods

Laboratory-reared Anopheles dirus were fed on blood from 119 Pf-infected Cambodian adults, with 5950 dissected to evaluate for transmitted infection. Among 12 persons who infected mosquitoes, polymerase chain reaction and amplicon deep sequencing were used to track species and clone-specific transmission to mosquitoes.

Results

Seven of 12 persons that infected mosquitoes harbored mixed Pf/Pv infection. Among these 7 persons, all transmitted Pv w

SUBMITTER: Balasubramanian S 

PROVIDER: S-EPMC7184918 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature