Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

ABSTRACT: Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs)^1,2, but so far there has been little scientific validation of this link. Here we report that, in mice, acute stress leads to hair greying through the fast depletion of melanocyte stem cells. Using a combination of adrenalectomy, denervation, chemogenetics^3,4, cell ablation and knockout of the adrenergic receptor specifically in melanocyte stem cells, we find that the stress-induced loss of melanocyte stem cells is independent of immune attack or adrenal stress hormones. Instead, hair greying results from activation of the sympathetic nerves that innervate the melanocyte stem-cell niche. Under conditions of stress, the activation of these sympathetic ne

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7184936 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature