Associations of maternal diet and placenta leptin methylation.

ABSTRACT:

Background

Maternal diet is an important factor in prenatal development that also has implications for disease risk later in life. The adipokine leptin is a key regulator of energy homeostasis and may be involved in the association between maternal nutrition, maternal obesity, and infant outcomes. DNA methylation of placenta genes may occur in response to exposures and may program subsequent infant development. This study examined maternal diet, placenta leptin gene DNA methylation, and neonatal growth in a sample of healthy neonates and their mothers.

Methods

Mothers and their healthy neonates (N = 135) were recruited within 1-2 days following delivery at Women and Infants Hospital in Providence, RI. A structured interview was conducted to assess maternal dietary intake. Ma

SUBMITTER: Daniels TE 

PROVIDER: S-EPMC7185035 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature