Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice.

ABSTRACT: Hypothalamic astrocytes are important contributors that activate gonadotropin-releasing hormone (GnRH) neurons and promote GnRH/LH (luteinizing hormone) surge. However, the potential roles and mechanisms of astrocytes during the early reproductive decline remain obscure. The current study reported that, in intact middle-aged female mice, astrocytes within the hypothalamic RP3V accumulated senescence-related markers with increasing age. It employed an ovariectomized animal model and a cell model receiving estrogen intervention to confirm the estrogen-induced senescence of hypothalamic astrocytes. It found that estrogen metabolites may be an important factor for the estrogen-induced astrocyte senescence. In vitro molecular analysis revealed that ovarian estradiol activated PKA and up-regulat

SUBMITTER: Dai X 

PROVIDER: S-EPMC7185128 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature