STAT5A induced LINC01198 promotes proliferation of glioma cells through stabilizing DGCR8.

ABSTRACT:

Background

LINC01198 has been suggested to be able to predict overall prognosis for glioma; however, it has been little described in glioma.

Results

It was shown that LINC01198 was markedly enriched in neoplasmic tissues relative to normal controls; and that elevated LINC01198 significantly correlated with unfavorable overall prognosis. Moreover, activation of STAT5A, identified as transcription factor (TF), can induce the expression of LINC01198. DGCR8, a kind of RNA-binding proteins (RBPs), was identified to be able to bind with LINC01198 that can stabilize the DGCR8. Five differential miRNAs with most significant difference, including miR-21-5p, miR-34-5p, miR-1246, miR-4488 and miR-494, were obtainable after silencing of DGCR8.

Conclusions

Together, the data we pr

SUBMITTER: Tan C 

PROVIDER: S-EPMC7185146 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature