Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development.

ABSTRACT: Cathepsin protease genes are necessary for protein homeostasis in normal brain development and function. The diversity of the 15 cathepsin protease activities raises the question of what are the human brain expression profiles of the cathepsin genes during development from prenatal and infancy to childhood, adolescence, and young adult stages. This study, therefore, evaluated the cathepsin gene expression profiles in 16 human brain regions during development by quantitative RNA-sequencing data obtained from the Allen Brain Atlas resource. Total expression of all cathepsin genes was the lowest at the early prenatal stage which became increased at the infancy stage. During infancy to young adult phases, total gene expression was similar. Interestingly, the rank ordering of gene expression am

SUBMITTER: Hsu A 

PROVIDER: S-EPMC7185200 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature