Ontology highlight
ABSTRACT:
SUBMITTER: Messaoudi N
PROVIDER: S-EPMC7185220 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Messaoudi Nouredin N Cousineau Isabelle I Arslanian Elizabeth E Henault David D Stephen David D Vandenbroucke-Menu Franck F Dagenais Michel M Létourneau Richard R Plasse Marylène M Roy André A Lapointe Réal R Ysebaert Dirk D Trudel Dominique D Soucy Geneviève G Stagg John J Turcotte Simon S
Oncoimmunology 20200423 1
Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether CD73, the rate limiting enzyme that catalyzes the degradation of extracellular AMP into immunosuppressive adenosine, could be an immunological determinant of colorectal liver metastases (CRLMs). By immunofluorescence on tissue microarrays, intratumor ...[more]