Changes in miRNA expressions in the injured small intestine of mice following high‑dose radiation exposure.

ABSTRACT: The small intestine is one of the most highly regenerative and radiosensitive tissues in mammals, including humans. Exposure to high doses of ionizing radiation causes serious intestinal damage. Recently, several investigations have been conducted using radioprotective agents to determine ways for reducing intestinal damage caused by radiation exposure. However, a thorough understanding of functional changes occurring in the small intestine of mice exposed to high‑dose radiation is necessary for developing novel and more potent radioprotective agents. In this study, we examined changes in microRNA (miRNA/miR) expressions in the small intestine of mice at 72 h after X‑ray exposure (10 Gy). We identified seven upregulated miRNAs and six downregulated miRNAs in the small intestine of mice fol

SUBMITTER: Chiba M 

PROVIDER: S-EPMC7185298 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature