SIRT3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair.

ABSTRACT: Control of inflammation is critical for the treatment of nonhealing wounds, but a delicate balance exists between early inflammation that is essential for normal tissue repair and the pathologic inflammation that can occur later in the repair process. This necessitates the development of novel therapies that can target inflammation at the appropriate time during repair. Here, we found that SIRT3 is essential for normal healing and regulates inflammation in wound macrophages after injury. Under prediabetic conditions, SIRT3 was decreased in wound macrophages and resulted in dysregulated inflammation. In addition, we found that FABP4 regulates SIRT3 in human blood monocytes, and inhibition of FABP4 in wound macrophages decreases inflammatory cytokine expression, making FABP4 a viable target

SUBMITTER: Boniakowski AM 

PROVIDER: S-EPMC7185380 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature