More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.

ABSTRACT:

Background

Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).

Objectives

Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.

Study design

A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. During the first season (2016/2017), respiratory viruses were detected using inhouse real-time PCR. The second season (2017/2018), we implemented a diagnostic flowchart including a rapid molecular test f

SUBMITTER: Vos LM 

PROVIDER: S-EPMC7185605 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature