Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways.

ABSTRACT: Targeted therapy and immunotherapy have greatly improved the prognosis of patients with metastatic melanoma, but resistance to these therapeutic modalities limits the percentage of patients with long-lasting responses. Accumulating evidence indicates that a persisting subpopulation of melanoma cells contributes to resistance to targeted therapy or immunotherapy, even in patients who initially have a therapeutic response; however, the root mechanism of resistance remains elusive. To address this problem, we propose a new model, in which dynamic fluctuations of protein expression at the single-cell level and longitudinal reshaping of the cellular state at the cell-population level explain the whole process of therapeutic resistance development. Conceptually, we focused on two different pivot

SUBMITTER: Bai X 

PROVIDER: S-EPMC7185899 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature