Ontology highlight
ABSTRACT:
SUBMITTER: Basch M
PROVIDER: S-EPMC7185958 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Basch Marion M Wagner Mirjam M Rolland Stéphane S Carbonell Andres A Zeng Rachel R Khosravi Siavash S Schmidt Andreas A Aftab Wasim W Imhof Axel A Wagener Johannes J Conradt Barbara B Wagener Nikola N
Molecular biology of the cell 20200212 8
The mitochondrial AAA ATPase Msp1 is well known for extraction of mislocalized tail-anchored ER proteins from the mitochondrial outer membrane. Here, we analyzed the extraction of precursors blocking the import pore in the outer membrane. We demonstrate strong genetic interactions of Msp1 and the proteasome with components of the TOM complex, the main translocase in the outer membrane. Msp1 and the proteasome both contribute to the removal of arrested precursor proteins that specifically accumul ...[more]