A New Hope for CD56^negCD16^pos NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases.

ABSTRACT: Natural Killer (NK) cells play an essential role in antiviral and anti-tumoral immune responses. In peripheral blood, NK cells are commonly classified into two major subsets: CD56^brightCD16^neg and CD56^dimCD16^pos despite the characterization of a CD56^negCD16^pos subset 25 years ago. Since then, several studies have described the prevalence of an CD56^negCD16^pos NK cell subset in viral non-controllers as the basis for their NK cell dysfunction. However, the mechanistic basis for their cytotoxic impairment is unclear. Recently, using a strict flow cytometry gating strategy to exclude monocytes, we reported an accumulation of CD56^negCD16^pos NK cells in Plasmodium falciparum malari

SUBMITTER: Forconi CS 

PROVIDER: S-EPMC7186373 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature