Distinct Synchronous Network Activity During the Second Postnatal Week of Medial Entorhinal Cortex Development.

ABSTRACT: The medial entorhinal cortex (MEC) contains specialized cell types whose firing is tuned to aspects of an animal's position and orientation in the environment, reflecting a neuronal representation of space. The spatially tuned firing properties of these cells quickly emerge during the third postnatal week of development in rodents. Spontaneous synchronized network activity (SSNA) has been shown to play a crucial role in the development of neuronal circuits prior to week 3. SSNA in MEC is well described in rodents during the first postnatal week, but there are little data about its development immediately prior to eye opening and spatial exploration. Furthermore, existing data lack single-cell resolution and are not integrated across layers. In this study, we addressed the question of wheth

SUBMITTER: Dawitz J 

PROVIDER: S-EPMC7186407 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature