Distinct Components in the Right Extended Frontal Aslant Tract Mediate Language and Working Memory Performance: A Tractography-Informed VBM Study.

ABSTRACT: The extended frontal aslant tract (exFAT) is a tractography-based extension of the frontal aslant tract (FAT) which has been shown to be related with language and working memory performance in healthy human adults, but whether those functional implications map to structurally separate regions along its trajectory is still an open question. We present a tractography-informed Voxel-Based Morphometry procedure capable of detecting local tract-specific structural differences in white matter regions and apply it in two maximum variation sampling studies by comparing local differences in diffusion-derived microstructural parameters and fiber density along the exFAT territory between top performers and bottom performers in language and working memory tasks. In the right hemisphere we were able to

SUBMITTER: Varriano F 

PROVIDER: S-EPMC7186483 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature