An alternative penicillin-binding protein involved in Salmonella relapses following ceftriaxone therapy.

ABSTRACT:

Background

Salmonella causes intracellular infections in humans. Besides quinolones, third generation cephalosporins are first line drugs used for salmonellosis therapy. An unresolved anomaly of this practice involves high relapse rates associated to quinolone- or cephalosporin-susceptible Salmonella isolates in patients that are discharged clinically following initial recovery. Reduced drug accessibility to intracellular locations has been hypothesized to impair pathogen eradication although supporting evidence is lacking in vivo. Here, we uncover a novel penicillin-binding protein as the first Salmonella factor likely contributing to relapse following beta-lactam, mainly ceftriaxone, therapy.

Methods

We used Salmonella enterica serovar Typhimurium mutants lacking the alter

SUBMITTER: Castanheira S 

PROVIDER: S-EPMC7186495 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature