Identification of epigenetic methylation-driven signature and risk loci associated with survival for colon cancer.

ABSTRACT:

Background

Abnormal methylation is associated with the survival of colon cancer. This study intended to discover a significant model based on methylation-driven genes (MDGs) and screen relative risk loci to assist with determining the prognoses of colon cancer patients.

Methods

We downloaded transcriptome expression profiles and 450K methylation data from the TCGA database. We then collected the two normalized profiles and utilized the MethylMix package to identify a significant signature showing the aberrantly methylated events highly correlated with expression levels. Also, functional enriched pathway analysis based on the ConsensusPathDB database was conducted to further explore the underlying cancer-related crosstalk among the identified MDGs. To find the significant MDG

SUBMITTER: Wang X 

PROVIDER: S-EPMC7186601 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature