1H-NMR based metabolomic profiling of cord blood in gestational hypothyroidism.

ABSTRACT:

Background

Gestational hypothyroidism (GHT) is a common pregnancy-related thyroid disfunction. The adverse outcomes by GHT has been increasingly recognized, leading to more public awareness of the disease. However, comprehensive understanding of the prognosis of GHT has not yet achieved. Metabolomics is a powerful tool in evaluation of disease outcomes, and cord blood represents an excellent candidate for the investigation of gestational outcomes.

Methods

In the present study, we performed 1H-NMR based metabolomics on cord blood of 18 pregnant women with GHT and 18 non hypothyroidism (NHT) control.

Results

The metabolomic profile of GHT was separated with the NHT control. A total of 8 metabolites with altered abundances were observed, among which Creatinine and O-Phos

SUBMITTER: Zhao C 

PROVIDER: S-EPMC7186693 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature