Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival.

ABSTRACT:

Background

N6-methyladenosine (m6A) modification holds an important position in tumorigenesis and metastasis because it can change gene expression and even function in multiple levels including RNA splicing, stability, translocation and translation. In present study, we aim to conducted comprehensive investigation on m6A RNA methylation regulators and m6A-related genes in pancreatic cancer and their association with survival time.

Methods

Based on Univariate Cox regression analysis, protein-protein interaction analysis, LASSO Cox regression, a risk prognostic model, STRING, Spearman and consensus clustering analysis, data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) database was used to analyze 15 m6A RNA methylation regulators th

SUBMITTER: Geng Y 

PROVIDER: S-EPMC7186697 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature