Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke.

ABSTRACT:

Background

Oxidative damage may contribute to post-stroke cognitive impairment (PSCI), but the underlying mechanisms are not fully elucidated. Dimethyl fumarate (DMF) has been used as an antioxidant in multiple sclerosis and psoriasis patients. We hypothesized that redox state was associated with PSCI, and DMF might exert neuroprotective effect against PSCI via anti-oxidative actions.

Methods

To confirm this hypothesis, we first conducted a clinical study (NCT03519828) that enrolled patients diagnosed with acute ischemic stroke within 48 hours. Data were analyzed based on demographic characteristics, disease history, clinical data and redox state. Logistic regression was used to identify the factors associated with PSCI. Next, a middle cerebral artery occlusion (MCAO) rat mo

SUBMITTER: Hou X 

PROVIDER: S-EPMC7186746 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature