Palladium Complexes Based on Ylide-Functionalized Phosphines (YPhos): Broadly Applicable High-Performance Precatalysts for the Amination of Aryl Halides at Room Temperature.

ABSTRACT: Palladium allyl, cinnamyl, and indenyl complexes with the ylide-substituted phosphines Cy₃ P⁺ -C^- (R)PCy₂ (with R=Me (L1) or Ph (L2)) and Cy₃ P⁺ -C^- (Me)PtBu₂ (L3) were prepared and applied as defined precatalysts in C-N coupling reactions. The complexes are highly active in the amination of 4-chlorotoluene with a series of different amines. Higher yields were observed with the precatalysts in comparison to the in situ generated catalysts. Changes in the ligand structures allowed for improved selectivities by shutting down β-hydride elimination or diarylation reactions. Particularly, the complexes based on L2 (joYPhos) revealed to be universal precatalysts for various amines and aryl halides. Full conve

SUBMITTER: Tappen J 

PROVIDER: S-EPMC7186839 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature