Association Between Spatial Heterogeneity Within Nonmetastatic Gastroesophageal Adenocarcinomas and Survival.

ABSTRACT:

Importance

Intratumoral heterogeneity has been recognized as a significant barrier in successfully developing targetable biomarkers for gastroesophageal adenocarcinoma (GEA) and may affect neoadjuvant precision medicine approaches.

Objective

To describe intratumoral spatial heterogeneity of tumor cell populations in nonmetastatic GEA and its association with survival.

Design, setting, and participants

This case series retrospectively identified 41 patients with GEA who underwent up-front surgical resection at a tertiary referral cancer center from January 1, 1989, through December 31, 2013. Survival was calculated from date of surgery to date of death through June 1, 2017. Data were analyzed from June 2, 2017, to March 1, 2019.

Main outcomes and measures

Overal

SUBMITTER: Chao J 

PROVIDER: S-EPMC7186861 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature