Polygenic Multiple Sclerosis Risk and Population-Based Childhood Brain Imaging.

ABSTRACT:

Objective

Multiple sclerosis (MS) is a neurological disease with a substantial genetic component and immune-mediated neurodegeneration. Patients with MS show structural brain differences relative to individuals without MS, including smaller regional volumes and alterations in white matter (WM) microstructure. Whether genetic risk for MS is associated with brain structure during early neurodevelopment remains unclear. In this study, we explore the association between MS polygenic risk scores (PRS) and brain imaging outcomes from a large, population-based pediatric sample to gain insight into the underlying neurobiology of MS.

Methods

We included 8- to 12-year-old genotyped participants from the Generation R Study in whom T1-weighted volumetric (n = 1,136) and/or diffusion ten

SUBMITTER: de Mol CL 

PROVIDER: S-EPMC7187244 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature