Disease severity and proton pump inhibitor use impact strongest on faecal microbiome composition in liver cirrhosis.

ABSTRACT:

Background & aims

Compositional changes of the faecal microbiome in cirrhosis are well described and have been associated with complications and prognosis. However, it is less well known, which disease or treatment-related factors affect microbiome composition most distinctively.

Methods

16S rDNA sequencing data of 88 cirrhotic outpatients were investigated. Factors influencing microbiome composition were analysed by univariate and multivariate redundancy analysis. The association of the identified factors with changes in diversity and taxonomic composition was studied in depth using analysis of composition of microbiome, LDA-effect size and least absolute shrinkage and selection operator regularized regression.

Results

Disease severity and aetiology, proton pump inhi

SUBMITTER: Stadlbauer V 

PROVIDER: S-EPMC7187411 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature