The cost-effectiveness of progesterone in preventing miscarriages in women with early pregnancy bleeding: an economic evaluation based on the PRISM trial.

ABSTRACT:

Objectives

To assess the cost-effectiveness of progesterone compared with placebo in preventing pregnancy loss in women with early pregnancy vaginal bleeding.

Design

Economic evaluation alongside a large multi-centre randomised placebo-controlled trial.

Setting

Forty-eight UK NHS early pregnancy units.

Population

Four thousand one hundred and fifty-three women aged 16-39 years with bleeding in early pregnancy and ultrasound evidence of an intrauterine sac.

Methods

An incremental cost-effectiveness analysis was performed from National Health Service (NHS) and NHS and Personal Social Services perspectives. Subgroup analyses were carried out on women with one or more and three or more previous miscarriages.

Main outcome measures

Cost per additional l

SUBMITTER: Okeke Ogwulu CB 

PROVIDER: S-EPMC7187468 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature