Estimation of inbreeding and identification of regions under heavy selection based on runs of homozygosity in a Large White pig population.

ABSTRACT:

Background

Runs of homozygosity (ROHs) are homozygous segments of the genome where the two haplotypes inherited from the parents are identical. The current availability of genotypes for a very large number of single nucleotide polymorphisms (SNPs) is leading to more accurate characterization of ROHs in the whole genome. Here, we investigated the occurrence and distribution of ROHs in 3,692 Large White pigs and compared estimates of inbreeding coefficients calculated based on ROHs (F _ROH), homozygosity (F _HOM), genomic relationship matrix (F _GRM) and pedigree (F _PED). Furthermore, we identified genomic regions with high ROH frequencies and annotated their candidate genes.

Results

In total, 176,182 ROHs we

SUBMITTER: Shi L 

PROVIDER: S-EPMC7187514 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature